Fascin and esophageal squamous cell carcinoma
نویسندگان
چکیده
منابع مشابه
Fascin and CK4 as biomarkers for esophageal squamous cell carcinoma.
BACKGROUND Several studies have suggested that fascin, cytokeratin 14 and cytokeratin 4 may have significant roles as biomarkers for the progression and survival of esophageal squamous cell carcinoma (ESCC). MATERIALS AND METHODS This study performed immunohistochemistry in tissue microarrays, profiling premalignant lesions and invasive tumors. RESULTS Fascin increased across the following ...
متن کاملImmunohistochemical Evaluation of Fascin in Oral Squamous Cell Carcinoma
Background and purpose: Squamous cell carcinoma (SCC) is the eighth most common cancer in men and the fifteenth in women. Localized recurrence and metastasis to regional lymph nodes are major problems in these patients. Fascin is a 55- kDa protein from the family of actin-binding proteins that is expressed in cells with membranous bronchial tubes. The aim of this study was to evaluate the expre...
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Objective(s): Epigenetic regulation of gene expression can be carried out through chromatin remodeling enzymes such as SWI/SNF. Brg1 also known as SMARCA4 is a catalytic subunit of SWI/SNF, which is necessary for MMPs expression. Matrix metalloproteinases (MMPs) are known as important player enzymes during tumor progression and metastasis. Aberrant epigenetic modification of chromatin should be...
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Telomerase activation is one of the main pathways to immortalize cancer cells. In many kinds of cancer cells, this special reverse transcriptase stabilizes and elongates telomeres and prevents telomere erosion that naturally occurs in every cell division. Esophageal cancer is the fifth most frequent cause of cancer death worldwide, and is highly associated with alcohol, smoking, cultural ha...
متن کاملEffects of small interfering RNAs targeting fascin on human esophageal squamous cell carcinoma cell lines
BACKGROUND Fascin induces membrane protrusions and cell motility. Fascin overexpression was associated with poor prognosis, and its downregulation reduces cell motility and invasiveness in esophageal squamous cell carcinoma (ESCC). Using a stable knockdown cell line, we revealed the effect of fascin on cell growth, cell adhesion and tumor formation. METHODS We examined whether fascin is a pot...
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ژورنال
عنوان ژورنال: Precision Radiation Oncology
سال: 2017
ISSN: 2398-7324
DOI: 10.1002/pro6.22